Pakpoom Kheolamai earned his M.D. (first class honours) from Chulalongkorn University in 2002. After received his medical degree, he went on to pursue his Ph.D. by studying the mechanisms underlying the differentiation process of mouse embryonic stem cells toward hepatocytes with Professor Alan Dickson at Faculty of Life Sciences, University of Manchester. After received his Ph.D. in 2006, he went back to Thailand to take a position as a lecturer, and then assistant professor at Division of Cell Biology, Faculty of Medicine, Thammasat University (Thailand). During this time, he has closely collaborated with Prof. Surapol Issaragrisil from Faculty of Medicine Siriraj hospital, Mahidol University, in studying the biology and clinical applications of various adult stem/progenitor cells. In 2010, he became a member of the newly established SiSCR where he continued his stem cell research. His recent work focuses on the biological properties of endothelial progenitor cells (EPCs) regarding their founding population, the factors that are required to induce their proliferation and differentiation as well as their roles in vascular homeostasis and vascular diseases. He also studies the biology of mesenchymal stem cells derived from both bone marrow and gestational tissues regarding their proliferation capacity, differentiation potential, immunomudulatory property and their clinical applications.

e-mail: pkheolamai@me.com


Publications

  1. Pomduk, K., Kheolamai, P., U-pratya, Y., Wattanapanitch, M., Klincumhom, N., and Issaragrisil, S., Enhanced human mesenchymal stem cell survival under oxidative stress by overexpression of secreted frizzled-related protein 2 gene. Ann Hematol, 2014.

  2. Wattanapanitch, M., Klincumhom, N., Potirat, P., Amornpisutt, R., Lorthongpanich, C., U-pratya, Y., Laowtammathron, C., Kheolamai, P., Poungvarin, N., and Issaragrisil, S., Dual Small-Molecule Targeting of SMAD Signaling Stimulates Human Induced Pluripotent Stem Cells toward Neural Lineages. PLoS One, 2014. 9(9): p. e106952.

  3. Sanvoranart, T., Supokawej, A., Kheolamai, P., U-pratya, Y., Klincumhom, N., Manochantr, S., Wattanapanitch, M., and Issaragrisil, S., Bortezomib enhances the osteogenic differentiation capacity of human mesenchymal stromal cells derived from bone marrow and placental tissues. Biochem Biophys Res Commun, 2014. 447(4): p. 580-5.

  4. Supokawej, A., Kheolamai, P., Nartprayut, K., U-pratya, Y., Manochantr, S., Chayosumrit, M., and Issaragrisil, S., Cardiogenic and myogenic gene expression in mesenchymal stem cells after 5-azacytidine treatment. Turk J Haematol, 2013. 30(2): p. 115-21.

  5. Tantrawatpan, C., Manochantr, S., Kheolamai, P., U-pratya, Y., Supokawej, A., and Issaragrisil, S., Pluripotent gene expression in mesenchymal stem cells from human umbilical cord Wharton’s jelly and their differentiation potential to neural-like cells. J Med Assoc Thai, 2013. 96(9): p. 1208-17.

  6. Nartprayut, K., U-pratya, Y., Kheolamai, P., Manochantr, S., Chayosumrit, M., Issaragrisil, S., and Supokawej, A., Cardiomyocyte differentiation of perinatallyderived mesenchymal stem cells. Mol Med Rep, 2013. 7(5): p. 1465-9.

  7. Manochantr, S., U-pratya, Y., Kheolamai, P., Rojphisan, S., Chayosumrit, M., Tantrawatpan, C., Supokawej, A., and Issaragrisil, S., Immunosuppressive properties of mesenchymal stromal cells derived from amnion, placenta, Wharton’s jelly and umbilical cord. Intern Med J, 2013. 43(4): p. 430-9.

  8. Jiraritthamrong, C., Kheolamai, P., U-pratya, Y., Chayosumrit, M., Supokawej, A., Manochantr, S., Tantrawatpan, C., Sritanaudomchai, H., and Issaragrisil, S., In vitro vessel-forming capacity of endothelial progenitor cells in high glucose conditions. Ann Hematol, 2012. 91(3): p. 311-20.

  9. Sudchada, S., Kheolamai, P., U-pratya, Y., Chayosumrit, M., Supokawej, A., Manochantr, S., Tantrawatpan, C., Sritanaudomchai, H., and Issaragrisil, S., CD14-/CD34+ is the founding population of umbilical cord blood-derived endothelial progenitor cells and angiogenin1 is an important factor promoting the colony formation. Ann Hematol, 2012. 91(3): p. 321-9.

  10. Manochantr, S., Tantrawatpan, C., Kheolamai, P., U-pratya, Y., Supokawej, A., and Issaragrisil, S., Isolation, characterization and neural differentiation potential of amnion derived mesenchymal stem cells. J Med Assoc Thai, 2010. 93 Suppl 7: p. S183-91.

  11. Suwannarurk, K., Bhamarapravatana, K., Kheolamai, P., Thaweekul, Y., Mairaing, K., Poomtavorn, Y., and Pattaraarchachai, J., Do health care providers have a lower prevalence of abnormal pap smears than the general public? J Med Assoc Thai, 2010. 93 Suppl 7: p. S114-9.

  12. Suwannarurk, K., Bhamarapravatana, K., Kheolamai, P., Thaweekul, Y., Mairaing, K., Poomtavorn, Y., and Pattaraarchachai, J., Can self vaginal douching for high risk HPV screening replace or assist efficacy of cervical cancer screening? Asian Pac J Cancer Prev, 2010. 11(5): p. 1397-401.

  13. Churdchomjan, W., Kheolamai, P., Manochantr, S., Tapanadechopone, P., Tantrawatpan, C., U-pratya, Y., and Issaragrisil, S., Comparison of endothelial progenitor cell function in type 2 diabetes with good and poor glycemic control. BMC Endocr Disord, 2010. 10: p. 5.

  14. Kheolamai, P. and Dickson, A.J., Liver-enriched transcription factors are critical for the expression of hepatocyte marker genes in mES-derived hepatocyte-lineage cells. BMC Mol Biol, 2009. 10: p. 35.

Pakpoom Kheolamai earned his M.D. (first class honours) from Chulalongkorn University in 2002. After received his medical degree, he went on to pursue his Ph.D. by studying the mechanisms underlying the differentiation process of mouse embryonic stem cells toward hepatocytes with Professor Alan Dickson at Faculty of Life Sciences, University of Manchester. After received his Ph.D. in 2006, he went back to Thailand to take a position as a lecturer, and then assistant professor at Division of Cell Biology, Faculty of Medicine, Thammasat University (Thailand). During this time, he has closely collaborated with Prof. Surapol Issaragrisil from Faculty of Medicine Siriraj hospital, Mahidol University, in studying the biology and clinical applications of various adult stem/progenitor cells. In 2010, he became a member of the newly established SiSCR where he continued his stem cell research. His recent work focuses on the biological properties of endothelial progenitor cells (EPCs) regarding their founding population, the factors that are required to induce their proliferation and differentiation as well as their roles in vascular homeostasis and vascular diseases. He also studies the biology of mesenchymal stem cells derived from both bone marrow and gestational tissues regarding their proliferation capacity, differentiation potential, immunomudulatory property and their clinical applications.

e-mail: pkheolamai@me.com


Publications

  1. Pomduk, K., Kheolamai, P., U-pratya, Y., Wattanapanitch, M., Klincumhom, N., and Issaragrisil, S., Enhanced human mesenchymal stem cell survival under oxidative stress by overexpression of secreted frizzled-related protein 2 gene. Ann Hematol, 2014.

  2. Wattanapanitch, M., Klincumhom, N., Potirat, P., Amornpisutt, R., Lorthongpanich, C., U-pratya, Y., Laowtammathron, C., Kheolamai, P., Poungvarin, N., and Issaragrisil, S., Dual Small-Molecule Targeting of SMAD Signaling Stimulates Human Induced Pluripotent Stem Cells toward Neural Lineages. PLoS One, 2014. 9(9): p. e106952.

  3. Sanvoranart, T., Supokawej, A., Kheolamai, P., U-pratya, Y., Klincumhom, N., Manochantr, S., Wattanapanitch, M., and Issaragrisil, S., Bortezomib enhances the osteogenic differentiation capacity of human mesenchymal stromal cells derived from bone marrow and placental tissues. Biochem Biophys Res Commun, 2014. 447(4): p. 580-5.

  4. Supokawej, A., Kheolamai, P., Nartprayut, K., U-pratya, Y., Manochantr, S., Chayosumrit, M., and Issaragrisil, S., Cardiogenic and myogenic gene expression in mesenchymal stem cells after 5-azacytidine treatment. Turk J Haematol, 2013. 30(2): p. 115-21.

  5. Tantrawatpan, C., Manochantr, S., Kheolamai, P., U-pratya, Y., Supokawej, A., and Issaragrisil, S., Pluripotent gene expression in mesenchymal stem cells from human umbilical cord Wharton’s jelly and their differentiation potential to neural-like cells. J Med Assoc Thai, 2013. 96(9): p. 1208-17.

  6. Nartprayut, K., U-pratya, Y., Kheolamai, P., Manochantr, S., Chayosumrit, M., Issaragrisil, S., and Supokawej, A., Cardiomyocyte differentiation of perinatallyderived mesenchymal stem cells. Mol Med Rep, 2013. 7(5): p. 1465-9.

  7. Manochantr, S., U-pratya, Y., Kheolamai, P., Rojphisan, S., Chayosumrit, M., Tantrawatpan, C., Supokawej, A., and Issaragrisil, S., Immunosuppressive properties of mesenchymal stromal cells derived from amnion, placenta, Wharton’s jelly and umbilical cord. Intern Med J, 2013. 43(4): p. 430-9.

  8. Jiraritthamrong, C., Kheolamai, P., U-pratya, Y., Chayosumrit, M., Supokawej, A., Manochantr, S., Tantrawatpan, C., Sritanaudomchai, H., and Issaragrisil, S., In vitro vessel-forming capacity of endothelial progenitor cells in high glucose conditions. Ann Hematol, 2012. 91(3): p. 311-20.

  9. Sudchada, S., Kheolamai, P., U-pratya, Y., Chayosumrit, M., Supokawej, A., Manochantr, S., Tantrawatpan, C., Sritanaudomchai, H., and Issaragrisil, S., CD14-/CD34+ is the founding population of umbilical cord blood-derived endothelial progenitor cells and angiogenin1 is an important factor promoting the colony formation. Ann Hematol, 2012. 91(3): p. 321-9.

  10. Manochantr, S., Tantrawatpan, C., Kheolamai, P., U-pratya, Y., Supokawej, A., and Issaragrisil, S., Isolation, characterization and neural differentiation potential of amnion derived mesenchymal stem cells. J Med Assoc Thai, 2010. 93 Suppl 7: p. S183-91.

  11. Suwannarurk, K., Bhamarapravatana, K., Kheolamai, P., Thaweekul, Y., Mairaing, K., Poomtavorn, Y., and Pattaraarchachai, J., Do health care providers have a lower prevalence of abnormal pap smears than the general public? J Med Assoc Thai, 2010. 93 Suppl 7: p. S114-9.

  12. Suwannarurk, K., Bhamarapravatana, K., Kheolamai, P., Thaweekul, Y., Mairaing, K., Poomtavorn, Y., and Pattaraarchachai, J., Can self vaginal douching for high risk HPV screening replace or assist efficacy of cervical cancer screening? Asian Pac J Cancer Prev, 2010. 11(5): p. 1397-401.

  13. Churdchomjan, W., Kheolamai, P., Manochantr, S., Tapanadechopone, P., Tantrawatpan, C., U-pratya, Y., and Issaragrisil, S., Comparison of endothelial progenitor cell function in type 2 diabetes with good and poor glycemic control. BMC Endocr Disord, 2010. 10: p. 5.

  14. Kheolamai, P. and Dickson, A.J., Liver-enriched transcription factors are critical for the expression of hepatocyte marker genes in mES-derived hepatocyte-lineage cells. BMC Mol Biol, 2009. 10: p. 35.