Chanchao Lorthongpanich received her Ph.D. from Suranaree University of Technology, where she studied mammalian embryo development and stem cell biology. In 2009, she joined the laboratory of Davor Solter and Barbara Knowles at the A*STAR Institute of Medical Biology (Singapore) as a postdoctoral research fellow to follow her interest in developmental biology. Her focus was to identify factors affecting lineage differentiation in preimplantation embryo. Her work demonstrated that not only the positional-information, but also proper expression levels of Hippo component genes play significant role in lineage segregation and differentiation in preimplantation embryos. In 2013, she joined Prof. Surapol Issaragrisil’s laboratory at the SiSCR as a researcher to continue her research interest in investigating the role of Hippo signaling pathway in mammalian embryo and stem cells.



1. Lorthongpanich, C., Cheow, LF., Balu, S., Quake, SR., Knowles, BB., Burkholder, WF., Solter, D and Messerschmidt, DM. Single-Cell DNA-methylation analysis reveals epigenetic chimerism in preimplantation embryos. Science. 2013; 341 (6150), 1110-1112.

2. Lim, AK., Lorthongpanich, C., Chew, TG., Tan, CWG., Shue, YT., Balu, S., Gounko, N., Kuramochi-Miyagawa, M.,  Matzuk, MM., Chuma, M., Messerschmidt, DM., Solter, D and Knowles, BB.  The nuage mediates retrotransposon silencing in mouse primordial ovarian follicles. Development. 2013; 40 (18), 3819-3825.

3. Lorthongpanich C, Messerschmidt DM, Chan SW, Hong W, Knowles BB, Solter D. Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation. Genes and Development. 2013; 27(13):1441-6.

4. Do DV, Ueda J, Messerschmidt DM, Lorthongpanich C, Zhou Y, Feng B, Guo G, Lin PJ, Hossain MZ, Zhang W, Moh A, Wu Q, Robson P, Ng HH, Poellinger L, Knowles BB, Solter D, Fu XY. A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo. Genes and Development. 2013; 27(12):1378-90.

5. Chew TG, Peaston A, Lim AK, Lorthongpanich C, Knowles BB, Solter D. A Tudor Domain Protein SPINDLIN1 Interacts with the mRNA-Binding Protein SERBP1 and Is Involved in Mouse Oocyte Meiotic Resumption. PLoS ONE. 2013; 8(7).

6. Lorthongpanich C, Doris TPY, Limviphuvadh V, Knowles BB, Solter D. Developmental fate and lineage commitment of singled mouse blastomeres. Development (Cambridge). 2012; 139(20):3722-31.

7. Chew TG, Lorthongpanich C, Ang WX, Knowles BB, Solter D. Symmetric cell division of the mouse zygote requires an actin network. Cytoskeleton. 2012; 69(12):1040-6.

8. Thumanu K, Tanthanuch W, Ye D, Sangmalee A, Lorthongpanich C, Parnpai R, Heraudd P. Spectroscopic signature of mouse embryonic stem cell-derived hepatocytes using synchrotron Fourier transform infrared microspectroscopy. Journal of Biomedical Optics. 2011; 16(5).

9. Lorthongpanich C, Solter D, Lim CY. Nuclear reprogramming in zygotes. International Journal of Developmental Biology. 2011; 54(11-12):1631-40.

10. Lorthongpanich C, Laowtammathron C, Parnpai R. From microsurgery to single blastomere biopsy for ES cell establishment. Thai Journal of Veterinary Medicine. 2011; 41(1):11-22.

11. Imsoonthornruksa S, Lorthongpanich C, Sangmalee A, Srirattana K, Laowtammathron C, Tunwattana W, Somsa W, Ketudat-Cairns M, Nagai T, Parnpai R. The effects of manipulation medium, culture system and recipient cytoplast on in vitro development of intraspecies and intergeneric felid embryos. Journal of Reproduction and Development. 2011; 57(3):385-92.

12. Tanthanuch W, Thumanu K, Lorthongpanich C, Parnpai R, Heraud P. Neural differentiation of mouse embryonic stem cells studied by FTIR spectroscopy. Journal of Molecular Structure. 2010; 967(1-3):189-95.

13. Srirattana K, Lorthongpanich C, Laowtammathron C, Imsoonthornruksa S, Ketudat-Cairns M, Phermthai T, Nagai T, Parnpai R. Effect of donor cell types on developmental potential of cattle (Bos taurus) and swamp buffalo (Bubalus bubalis) cloned embryos. Journal of Reproduction and Development. 2010; 56(1):49-54.

14. Laowtammathron C, Cheng ECH, Cheng PH, Snyder BR, Yang SH, Johnson Z, Lorthongpanich C, Kuo HC, Parnpai R, Chan AWS. Monkey hybrid stem cells develop cellular features of Huntington’s disease. BMC Cell Biology. 2010; 11.

15. Imsoonthornruksa S, Lorthongpanich C, Sangmalee A, Srirattana K, Laowtammathron C, Tunwattana W, Somsa W, Ketudat-Cairns M, Parnpai R. Abnormalities in the transcription of reprogramming genes related to global epigenetic events of cloned endangered felid embryos. Reproduction, Fertility and Development. 2010; 22(4):613-24.

16. Thumanu K, Tanthanuch W, Lorthongpanich C, Heraud P, Parnpai R. FTIR microspectroscopic imaging as a new tool to distinguish chemical composition of mouse blastocyst. Journal of Molecular Structure. 2009; 933(1-3):104-11.

17. Lorthongpanich C, Yang SH, Piotrowska-Nitsche K, Parnpai R, Chan AWS. Development of single mouse blastomeres into blastocysts, outgrowths and the establishment of embryonic stem cells. Reproduction. 2008; 135(6):805-13.

18. Lorthongpanich C, Yang SH, Piotrowska-Nitsche K, Parnpai R, Chan AWS. Erratum: Development of single mouse blastomeres into blastocysts, outgrowths and the establishment of embryonic stem cells (Reproduction vol. 135 (6) (808)). Reproduction. 2008; 136(2):275.